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Prostate Cancer
Treatment Guide™

Experts in Treating Prostate Cancer
Treatment
Description
Prostate Cancer
Patient Profile
Prostate Cancer
Treatments
Prostate Cancer
Survival Rates
Prostate Cancer
Side Effects
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Hormone
Therapy

Prostate Hormone Therapy

Prostate hormone therapy suppresses, blocks, or eliminates testosterone to slow the tumor’s growth. Prostate Hormone
Therapy

Prostate hormone therapy suppresses, blocks, or eliminates testosterone to slow the tumor’s growth.

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Hormone Therapy Uses

Therapy can slow the tumor’s growth or lower a PSA level; it may be used before, during, or after other treatment. Hormone Therapy Uses

Therapy can slow the tumor’s growth or lower a PSA level; it may be used before, during, or after other treatment.

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Shrinking the Prostate

Surgical castration patients return home the day of the surgery. Treatment is given orally or by injection. Shrinking the Prostate

Surgical castration patients return home the day of the surgery. Treatment is given orally or by injection.

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Hormone
Therapy Effects

Hormone therapy does not destroy cancer but research has shown effectiveness in enhancing other treatments. Hormone
Therapy Effects

Hormone therapy does not destroy cancer but research has shown effectiveness in enhancing other treatments.

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Hormone Therapy
Side Effects

May cause impotence, weight gain, hot flashes, fatigue, loss of muscle mass; and hormone “flare” in LHRH use. Hormone Therapy
Side Effects

May cause impotence, weight gain, hot flashes, fatigue, loss of muscle mass; and hormone “flare” in LHRH use.

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Prostate News

Click here for the latest news on Hormone Therapy.Prostate News

Click here for the latest news on Hormone Therapy.

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Hormone Therapy
Videos

Click here to view Hormone Therapy procedures. Hormone Therapy
Videos

Click here to view Hormone Therapy procedures.

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Hormone Therapy
Experiences


Click here to share your Hormone Therapy experiences.Hormone Therapy
Experiences

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Brachytherapy

Chemotherapy

Cryotherapy & Cryosurgery

Radiation
Therapy

Prostatectomy

Robotic Prostatectomy

Watchful
Waiting

Complementary
and
Alternative Medicine

High Intensity
Focused
Ultrasound (HIFU)

Emerging Technologies

 

Prostate Cancer Information:
Prostate Cancer Hormone Therapy

Prostate cancer hormone therapy is the systemic ablation of the body’s testosterone which, for a period of time, will slow or stop the growth and spread of prostate cancer. Hormone therapy may also be called androgen deprivation or androgen ablation.

The Role of Hormones in Prostate Cancer
The male sex hormone, testosterone, causes the growth of the prostate gland and other sex organs in the developing male. Even as men pass through the age of puberty, testosterone continues to contribute to the growth of the organ. Testosterone will fuel the growth of any prostatic cell: the chemical cannot discriminate between the receptors of healthy tissue and cancerous tissue. Prostate cancer hormone therapy removes the chemical that “feeds” cells and can stop or slow the growth and spread of the tumor.

Where does Testosterone Come From?
A chemical sequence in the brain signals the testicles, which make 90% of the body’s hormones, to begin production. A structure in the brain called the hypothalamus continually monitors the blood stream for adequate levels of testosterone. If these levels drop, the hypothalamus releases a chemical called GnRH (gonadotropin releasing hormone) or LHRH (luteinizing hormone releasing hormone). GnRH acts as a messenger and travels to the pituitary gland where it plugs into designated receptors.

The pituitary gland receives the message from the hypothalamus and releases Gn (gonadotropin) or LH (luteinizing hormone). Gonadotropin travels through the blood stream and stimulates the production of hormone in the testicles. Testosterone plugs into the receptors of the cells’ nuclei and helps them grow. The other 10 percent of testosterone is produced by the adrenal glands which are located close to the kidneys.

How is Hormone Therapy Administered?
There are four basic methods androgen deprivation: castration, estrogen, anti – androgens, and combine androgen blockade.

Castration uses orchiectomy, LHRG agonists, and LHRH antagonists to remove testicle-produced testosterone from the body. Orchiectomy surgically removes the testicles, while LHRH agonists and antagonists block the messenger process in the brain. A castrate level refers to having 90 to 95% testosterone less than that of a healthy male.

Estrogen is not commonly used to treat prostate cancer because the synthetic version – diethylstilbestrol – has been shown to cause serious cardiovascular problems. Estrogen is the female sex hormone and cannot feed the prostatic tissue, but the hypothalamus will mistake estrogen for testosterone and stop GnRH production.

Anti-androgens fill in the receptors of the cells. Testosterone circulates through the body but cannot interact with the prostate gland.

Combined androgen blockade uses both castration and anti-androgens to ablate testosterone 90% of testicle-produced hormone and to block the prostate’s ability to receive the hormone.

Methods of Delivering Prostate Cancer Hormone Therapy
Today, treatment is administered as neoadjuvant, adjuvant, and salvage therapy. Neoadjuvant is used before the primary treatment to shrink the prostate gland to an acceptable volume. Adjuvant is used while patients are undergoing treatments. Salvage is used when a primary treatment has failed.

Androgen ablation may also be used intermittently, for example, in periods of 6 months on and 6 months off. Some doctors believe intermittent therapy staves off the hormone refractory prostate cancer, which occurs when the disease stops responding to treatment and begins to grow again.

 
 
 

 
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