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Prostate Cancer Treatment Guide

Treatment
Description
Prostate Cancer
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Prostate Cancer
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Prostate Cancer
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Prostate Cancer
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Brachytherapy

Prostate Brachytherapy

Minimally invasive radiation therapy implants low or high dose radiation (LDR or HDR) seeds in the prostate. Prostate Brachytherapy

Minimally invasive radiation therapy implants low or high dose radiation (LDR or HDR) seeds in the prostate.

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Prostate Seed Implant

Brachytherapy seeds are more effective for younger patients in good health with localized prostate cancer. Prostate Seed Implant

Brachytherapy seeds are more effective for younger patients in good health with localized prostate cancer.

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Prostate Seed Implant

Minimally invasive surgery lasts 1-2 hours with a possible overnight stay; most return to normal activities in a few days. Prostate Seed Implant

Minimally invasive surgery lasts 1-2 hours with a possible overnight stay; most return to normal activities in a few days.

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Brachytherapy
Survival Rates

Multiple long-term brachytherapy studies have found recurrence-free survival rates of 77 to 93%. Brachytherapy
Survival Rates

Multiple long-term brachytherapy studies have found recurrence-free survival rates of 77 to 93%.

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Brachytherapy
Side Effects

Possible bleeding at the minimally invasive site, blood in the urine, scrotal burning, incontinence, or impotence. Brachytherapy
Side Effects

Possible bleeding at the minimally invasive site, blood in the urine, scrotal burning, incontinence, or impotence.

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Prostate News

Click here for the latest news on brachytherapy.Prostate News

Click here for the latest news on brachytherapy.

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Brachytherapy
Videos

Click here to view brachytherapy procedures. Brachytherapy
Videos

Click here to view brachytherapy procedures.

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Brachytherapy
Experienc
e

Click here to share your brachytherapy experiences.Brachytherapy
Experience

Click here to share your brachytherapy experiences.

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Chemotherapy

Cryosurgery &
Cryotherapy

Hormone
Therapy

Radiation
Therapy

Prostatectomy

Robotic Prostatectomy

Watchful
Waiting

Complementary
and
Alternative Medicine

High Intensity
Focused
Ultrasound (HIFU)

Emerging Technologies

 

Results of Treating Prostate Cancer with Brachytherapy and Seed Migration

“Radioactive Seed Migration to the Chest After Transperineal Interstitial Prostate Brachytherapy: Extraprostatic Seed Placement Correlates with Migration”
Jeffrey S. Eshleman, M.D., Brian J. Davis, M.D., PH.D., Thomas M. Pisansky, M.D., Torrence M. Wilson, M.D., Michael G. Haddock, M.D., Bernard F. King, M.D., Charles H. Darby, M.S., Wayne N. Lajoie, B.S., and Ann L. Oberg, PH.D. Int. J. Radiation Oncology Biol. Phys., Vol. 59, No. 2, pp. 419­425, 2004

Physicians evaluated 102 patients with stage T1 or T2 prostate cancer that underwent brachytherapy between May 1998 and April 2000. Of those patients only 100 fit the criteria necessary for this study. Chest X-rays (CXR) after treatment were studied for the number and location of radioactive seeds. Doctors then analyzed the link between patients, treatment variables, occurrence, and number of seed migrations. The results of the study found that 55% of the 100 patients had one or more seeds identified on the CXR. Out of 12 patients, 135 seeds were implanted, 119 or .98% were discovered on the CXR. In patients where migration occurred, generally 2.2 intrathoracic seeds were found. The amount of extraprostatic seeds planned was 43.9% and after the operation a CT image found 37.9% actually placed in this region. This study has concluded that extraprostatic placement of loose seeds may predict the likelihood and frequency of seed migration to the thorax.


“The Use of Linked Seeds Eliminates Lung Embolization Following Permanent Seed Implantation for Prostate Cancer”
Basher Al-Qaisieh, M.S.C., Brendan Carey, F.R.C.R., Dan Ash, F.R.C.R., and David Bottomley, F.R.C.R. Int. J. Radiation Oncology Biol. Phys., Vol. 59, No. 2, pp. 397-399, 2004

In an effort to reduce the risk of seed migration to the lungs after brachytherapy, physicians studied whether this side effect can be minimized with the use of stranded seeds alone for brachytherapy. Under this clinical trial 238 patients with early prostate cancer were treated between December 2001 and December 2002 with prostate brachytherapy implementing the stranded seed technique. During this procedure all patients had fluoroscopy and immediately following had radiographs of the pelvis. At an average of 55 days a sample of 100 patients had chest radiographs done. To make the seeds more visible, 4 prostate cancer free patients took part in this study. Since they were having routine chest radiographs for management of other cancers they allowed posteroanterior and lateral radiographs to be performed with inactive seeds attached to their thorax. After review it was revealed that in all 238 cases the number of seeds found on the preceding radiograph matched the number of seeds implanted. The results of this study concluded that with the use of stranded seeds for prostate brachytherapy there is no evidence that seeds migrated to the lung.


“Reduction of Radioactive Seed Embolization to the Lung Following Prostate Brachytherapy”
Elizabeth M. Tappen, M.D., John C. Blasko, M.D., Peter D. Grimm, D.O., Haakon Ragde, M.D., Ray Luse, M.S., Stephanie Clifford, John Sylvester, M.D., and Thomas W. Griffin, M.D. Int. J. Radiation Oncology Biol. Phys., Vol. 42, No. 5, pp. 1063-1067, 1998

This study focused on analyzing the incidence and possible negative effects of seed migration following prostate brachytherapy. Between January 1 and December 31, 1995, 290 consecutive patients were treated with brachytherapy for prostate cancer. Of that group, 154 patients received I-125 and 136 patients received Pd-103. With the exception of one, all patients had routine chest radiographs prior to the procedure, thus leaving 289 patients to evaluate. With respect to the entire group 5.9% exhibited a radioactive seed pulmonary rate with no reported acute symptoms. Those who were implanted with free seeds consisted of 146 patients and those with linked seeds embedded in a vicryl suture consisted of 143 patients. For free seed implants, 11% experienced a radioactive seed embolization rate and .7% of linked seed implants experienced the same. This statistic demonstrates that linked seeds embedded in vicryl sutures under this procedure reduced the occurrence of pulmonary seed embolization.

 
 
 
 

 
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