The LHRH Antagonist
is used in prostate cancer hormone therapy to control
the growth and spread of the prostate cancer through
testosterone ablation. An antagonist is a chemical agent
that mimics the shape of a natural agent and fills in
the receptor for the natural agent. While the antagonist
is in place, the natural agent cannot enter and communicate.
LHRH antagonist is a specific type of antagonist used
in prostate cancer hormone therapy. LHRH antagonist
mimics natural LHRH or luteinizing hormone-releasing
hormone and plugs into the receptors of the pituitary
gland. LHRH is the messenger between the hypothalamus
and the pituitary gland and it tells the pituitary gland
to produce LH which tells the testicles to produce more
testosterone. If LHRH antagonist is in the receptors
for natural LH, the pituitary gland never receives the
message and the levels of testosterone drop to castrate
level.
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