The GnRH antagonist
is used in prostate cancer hormone therapy to control
the growth and spread of the prostate cancer through
testosterone ablation. An antagonist is a chemical agent
that mimics the shape of a natural agent and fills in
the receptor for the natural agent. While the antagonist
is in place, the natural agent cannot enter and communicate.
GnRH antagonist is a specific type of antagonist used
in prostate cancer hormone therapy. GnRH antagonist
mimics natural GnRH or gonadotropin releasing hormone
and plugs into the receptors of the pituitary gland.
GnRH is the messenger between the hypothalamus and the
pituitary gland and it tells the pituitary gland to
produce GN which tells the testicles to produce more
testosterone. If GnRH antagonist is in the receptors
for natural GN, the pituitary gland never receives the
message and the levels of testosterone drop to castrate
level.
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